Bruce Dern claimed that he and Will Forte were stuck in the car for hours while filming the driving scenes due to cameras being mounted on both doors. Consequently they were unable to take bathroom breaks between takes. Dern remarked "We found out what bottles are for."
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Alexander Payne's first experience shooting in black and white, with digital cameras and anamorphic lenses. Paramount initially balked at Payne's choice to shoot in black and white, but relented when previews yielded positive feedback to the cinematography.
Unlike the alcoholic and limping character of Woody, Bruce Dern is a teetotaler who was an avid marathoner, and still practices running in his late-seventies.
In the scene with the cemetery there is a grave stone with the name Payne, a reference to Alexander Payne.
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The movie begins and ends with the 50s and 60s Paramount logo, saying "A Paramount Release".
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Alexander Payne tried to get the movie made for almost 10 years, and the big success of The descendants (2011) finally allowed him to do so.
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The first Alexander Payne film that he did not also write the screenplay for, and the first since Citizen Ruth (1996) whose screenplay is original and not adapted.
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Although all the major characters hail from Nebraska, three of the leading actors, Bruce Dern, June Squibb and Bob Odenkirk were born and raised in Illinois.
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Bryan Cranston auditioned for the role of David. If Cranston was cast, he would have played the sibling of Ross, played by his Breaking Bad co-star Bob Odenkirk.
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As needed, Alexander Payne put an audition in the news paper in Nebraska for the role of a stand-in, and Nebraska Bridget O'Brien got the part.
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Barbara Bain auditioned for a role.
Cameo
Bob Nelson: The movie's screenwriter can be seen sitting at a booth in the café when everyone is applauding for Woody.