-Villains in the Bond movie series have often had some physiological dysfunction or trait that makes them distinguishable. For this movie, the Raoul Silva villain played by Javier Bardem has a false jaw. This was caused by his attempted suicide when a hydrogen cyanide capsule implant in one his back left molar was broken open and left his mandible lower jawbone (aka the inferior maxillary jaw bone) physically scarred. Interestingly, Jaws from L'espion qui m'aimait (1977) and Moonraker (1979), another villain with a false jaw, is Bardem's favorite Bond villain. Similarly, Sévérine played by Bérénice Marlohe, who is initially represented as an antagonistic femme fatale working with Silva has the distinguishing feature of the the tattoo on her wrist. However, as her true character is explored, it is discovered the tattoo meant she belonged to the sex trade of Macau.
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-Second James Bond film to feature an attack on MI6 headquarters in London; the first was in Le monde ne suffit pas (1999). Similarly, a raid on MI6's countryside Blayden Safe House was seen in Tuer n'est pas jouer (1987).
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-Naomie Harris is the fourth actress in the official series to play Miss Moneypenny. Harris is the fifth if one counts Pamela Salem from the unofficial Jamais plus jamais (1983) and the sixth if one counts Barbara Bouchet from the unofficial Bond spoof Casino Royale (1967) where the character was technically Miss Moneypenny's daughter. Harris' Moneypenny is called Eve making her characterization the first time in the official series that the character has had a first name. 'Skyfall' is the first time the character has appeared in the series since Meurs un autre jour (2002), a gap of around a decade. Harris is also the first black actress to play the part. Lois Maxwell first played Moneypenny in 14 Bond films between 1962 and 1985 through all of the Connery, Lazenby and Moore movies. Maxwell was then followed by Caroline Bliss for two films during the Dalton era and then Samantha Bond for four films during the Brosnan era. 'Skyfall' represents the first time that Miss Moneypenny is a fully-fledged main Bond Girl and not a supporting character.